Relapsing Fever Borreliosis in Interleukin-10-Deficient Mice
نویسندگان
چکیده
منابع مشابه
Relapsing Fever Borreliosis in IL-10 Deficient Mice
* Corresponding author: Dr. Diego Cadavid, Center for Immunity and Inflammatory Diseases, 16 Massachusetts General Hospital, 149 13 th Street, Room 8301, Charlestown, MA 02129 17 Phone 617-6793680; fax 617-6793518; email: [email protected] 18 19 AC CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Infect. Immun. doi:10....
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Interleukin-10 (IL-10) affects the growth and differentiation of many hemopoietic cells in vitro; in particular, it is a potent suppressor of macrophage and T cell functions. In IL-10-deficient mice, generated by gene targeting, lymphocyte development and antibody responses are normal, but most animals are growth retarded and anemic and suffer from chronic enterocolitis. Alterations in intestin...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2008
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00587-08